Peanut Allergy in Adults: How Daily Exposure Could Be Life-Changing

At AllergyRhino, we’re committed to bringing the latest advancements in allergy care to our community. Today, we’re proud to highlight groundbreaking research led by our Clinical Director, Professor Stephen Till, that’s offering new hope to adults living with peanut allergies.

For many, peanut allergy isn’t just an inconvenience - it’s a daily source of anxiety, impacting everything from meals out with friends to travel plans. Until now, most treatments focused on children, leaving adults with one option: strict avoidance. But a new study from Guy’s and St Thomas’ NHS Foundation Trust, led by Professor Till, suggests that adults can also benefit from a promising approach known as oral immunotherapy (OIT).

The Landmark Study: Desensitising Adults to Peanuts

Published in the prestigious journal Allergy and widely covered by the BBC and The Guardian, this Phase II clinical trial is the first of its kind to focus solely on adults with peanut allergies. The study involved 21 adults aged 18-40, each with a confirmed peanut allergy. Under careful medical supervision, participants began with a tiny dose—less than 1/100th of a peanut—and gradually increased their daily intake over several weeks.

By the end of the trial, two-thirds of participants could safely consume the equivalent of five peanuts without experiencing an allergic reaction. Remarkably, the median tolerance increased 100-fold, from just 30mg to 3,000mg of peanut protein.

Real-World Approach, Real-Life Impact

One of the unique aspects of this study was its use of everyday peanut products - like peanut flour, whole peanuts, and peanut butter - rather than pharmaceutical-grade powders. This “real-world” approach not only makes treatment more accessible but also prepares patients for practical, day-to-day management after desensitisation.

Professor Stephen Till, who led the trial and also serves as Clinical Director here at AllergyRhino, explained:

“The constant fear of life-threatening reactions places a huge burden on adults with peanut allergies. This study shows that oral immunotherapy isn’t just for children - adults can also achieve desensitisation, improving both safety and quality of life.”

More Than Just Tolerance - A Better Quality of Life

Beyond increasing peanut tolerance, participants reported significant improvements in their mental wellbeing. Many described the treatment as “life-changing,” freeing them from the persistent fear of accidental exposure. Clinical assessments confirmed reduced anxiety around food, greater confidence in social situations, and an overall boost in quality of life.

Safety First When Dealing With Peanut Allergy: A Carefully Monitored Journey

While the results are encouraging, OIT isn’t without risks. Some participants experienced mild reactions during dose increases, and a few required adjustments to their treatment plans. However, with expert supervision - like that provided by Professor Till’s team - the majority safely reached their maintenance dose.

At AllergyRhino, patient safety is always our top priority. This study reinforces how structured, clinician-led desensitisation can offer adults a path forward, reducing fear without compromising wellbeing.

What This Means for the Future of Allergy Care

This research is a pivotal step in expanding treatment options for adults living with peanut allergies. While further studies are needed to refine protocols and ensure long-term safety, the message is clear: desensitisation isn’t just for kids.

Professor Till’s dual role - as a leading researcher in allergy immunotherapy and as Clinical Director at AllergyRhino - means we’re uniquely positioned to bring these innovations into clinical practice. We’re excited about the potential to offer personalised desensitisation programs.

Could Desensitisation Be Right for You?

If you’re living with a peanut allergy, the idea of introducing peanuts into your diet might sound daunting. But under the right medical guidance, it could transform your relationship with food - and your freedom.

Stay tuned to AllergyRhino for updates as we explore how these research findings can shape new services for adults with food allergies. As always, speak to your healthcare provider before considering any treatment changes.

For more information, you can read the full study published in Allergy here, or check out coverage from BBC News and The Guardian.